She attended Johnston County Training School in Smithfield. She later received her nursing certificate from Johnston Community College. She worked at Marlboro House and Colonial Rest Home until her retirement. 

Annie was a devoted member of several churches, including Wesley Chapel Church, Evans Chapel AME Church, Burning Bush Holiness Church, and New Life Deliverance Ministries. She faithfully served as a Church Mother until her health began to decline.

Annie was preceded in death by her husband, Richard Williams; her parents, Willis and Fannie Sanders; her children, Kenneth Williams and Aloysius Williams; and her siblings, Doris Hines, Janette Clinton, and Weston Sanders Jr.

She leaves to cherish her memories three daughters: Mynra Williams of New York, Cynthia Williams, and Brookie Glaspie, of Smithfield; two sisters, Peggie Taylor of New Jersey and Ethel Sanders of New Jersey; two sisters-in-law, Thelma Williams and Martha Williams of North Carolina; and one aunt, Dottie Sanders of Smithfield. She also leaves four grandchildren: Jeffrey Williams, Jasmine Douglas Kenan (Kendrick) of Smithfield, Alliyah Williams of New York, and Maynard Glaspie of Durham; eight great-grandchildren: Juelz Hinnant, Ivyonna Hinnant, Zyon Williams, Skylar Hinnant, Kendrick Kenan Jr., Kentrell Kenan, Kendrell “Exodus” Kenan, and Djedefre Williams; along with a host of other relatives and friends.